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Age-specific mortality and immunity patterns of SARS-CoV-2

https://www.nature.com/articles/s41586-020-2918-0

Estimating the size and infection severity of the SARS-CoV-2 epidemic is made challenging by inconsistencies in available data. The number of COVID-19 deaths is often used as a key indicator for the epidemic size, but observed deaths represent only a minority of all infections1,2.

Additionally, the heterogeneous burden in nursing homes and variable reporting of deaths in elderly individuals can hamper direct comparisons across countries of the underlying level of transmission and mortality rates3. Here we use age-specific COVID-19 death data from 45 countries and the results of 22 seroprevalence studies to investigate the consistency of infection and fatality patterns across multiple countries.

We find that the age distribution of deaths in younger age groups (<65 years) is very consistent across different settings and demonstrate how this data can provide robust estimates of the share of the population that has been infected.

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ANALYSIS: In Search for the virus, WHO let China take charge

 ...Nine months and more than 1.1 million deaths later, there is still no transparent, independent investigation into the source of the  (COVID-19) virus. Notoriously allergic to outside scrutiny, China has impeded the effort, while leaders of the World Health Organization, if privately frustrated, have largely ceded control, even as the Trump administration has fumed.

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Families, day cares feel strain of new COVID-19 health rules

.... As more families make the jump back to group day care this fall in an attempt to restart lives and careers, many parents, pediatricians and care operators are finding that new, pandemic-driven rules offer a much-needed layer of safety but also seem incompatible with the germy reality of childhood.

They stem largely from coronavirus guidelines issued by the Centers for Disease Control and Prevention lowering the fever threshold, disqualifying even a single bout of diarrhea or vomiting and making sniffles suspect in group settings.

But the guidelines don’t take into account that young children are prone to catching the common viral infections that help build up their immune systems, or that seasonal allergies, crying, even teething and normal playground exertion can prompt a COVID-19-like symptom.

And the price parents and kids pay for such symptoms — which could easily signal either a happy, healthy toddler, or a lurking case of the disease that has now killed more than 230,000 people in the U.S. — is now a dayslong disruption. ...uilt over neglecting work.

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A Rapid Virus Test Falters in People Without Symptoms, Study Finds

As the number of coronavirus cases in the United States exceeds 9.2 million, experts continue to call for a massive scale-up of testing among both the healthy and the sick — a necessary measure, they have said, to curb the spread of an infection that can move swiftly and silently through the population.

One strategy has involved the widespread use of rapid tests, which forgo sophisticated equipment and can return results in minutes. Purchased in bulk by the federal government and shipped nationwide, millions of these products have already found their way into clinics, nursing homes, schools, athletic teams’ facilities and more, buoying hopes that the tests might hasten a return to normalcy.

But a new study casts doubt on whether rapid tests perform as promised under real-world conditions, especially when used in people without symptoms.

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